Work Package 8
WP 8: Risk prediction/Diagnosis of Susceptibility and Progression of Osteoarthritis
- To utilise combinations of biochemical and genetic makers along with epidemiological risk factors in existing population-based cohorts to predict radiographic progression and clinical outcomes.
- To assess the value of such markers as diagnostic products capable of identifying individuals at high risk of developing OA and/or of progressing to severe hip and knee OA.
- To develop a diagnostic model in a subset of population based longitudinal cohort (n=2000) and confirm the positive and negative predictive values in five independent cohorts (n=8000).