Work Package 7

Work Package 7

WP 7: Functional Genomics: in vivo studies and animal models of OA

Participants:

Oxford,KU Leuven

Objectives:

  1. To test the role of selected genes in osteoarthritis in mice and to develop new genetic mouse models for OA that will facilitate the investigation of the pathogenesis of OA and provide models in which novel therapeutic targets can be tested.
  2. o screen the large-scale random N-ethylnitrosourea (ENU) mutagenesis resources established for mouse (WP7.1) and test selected genes in established postnatal models of OA triggered by instability, direct cartilage damage or inflammation in mice. (WP7.2).

Publications:

Wnt signaling and osteoarthritis. Luyten FP, Tylzanowski P, Lories RJ. Bone. 2009 Apr;44(4):522-7. Epub 2008 Dec 14.
Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Lories RJ, Peeters J, Bakker A, Tylzanowski P, Derese I, Schrooten J, Thomas JT, Luyten FP. Arthritis Rheum. 2007 Dec;56(12):4095-103.
Contemporary concepts of inflammation, damage and repair in rheumatic diseases. Luyten FP, Lories RJ, Verschueren P, de Vlam K, Westhovens R. Best Pract Res Clin Rheumatol. 2006 Oct;20(5):829-48.
Noggin haploinsufficiency differentially affects tissue responses in destructive and remodeling arthritis. Lories RJ, Daans M, Derese I, Matthys P, Kasran A, Tylzanowski P, Ceuppens JL, Luyten FP. Arthritis Rheum. 2006 Jun;54(6):1736-46.
Bone morphogenetic protein signaling in joint homeostasis and disease. Lories RJ, Luyten FP. Cytokine Growth Factor Rev. 2005 Jun;16(3):287-98.

Status:


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