Work Package 6
WP 6: Functional Genomics: in vivo studies and animal models of OA
KU Leuven,Hubrecht Institute
- To develop zebrafish and chick gain of function and loss of function models for OA related genes and pathways identified by human genetic approaches.
- To investigate, in vivo, the function of those genes in skeletal development and synovial joint formation by developing a chick model. Following the initial preselection of target genes in the zebrafish, a subset of those genes will be evaluated using developing chick limb in ovo.