Work Package 5

Work Package 5

WP 5: In vitro and Ex vivo models of OA


KU Leuven,Tigenix,Oxford,,LUMC,deCode


  1. To develop in vitro models for OA that will facilitate the investigation of the potential mode action of the identified genes associated with OA and look into models perceived as relevant to the disease process.
  2. To systematically screen in vitro mostly primary cells and tissues of relevance to the joint and joint associated tissues such as chondrocytes/cartilage, meniscal cells, osteoblasts/bone and mesenchymal stem cells/synovium.


Wnt signaling and osteoarthritis. Luyten FP, Tylzanowski P, Lories RJ. Bone. 2009 Apr;44(4):522-7. Epub 2008 Dec 14.
Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Lories RJ, Peeters J, Bakker A, Tylzanowski P, Derese I, Schrooten J, Thomas JT, Luyten FP. Arthritis Rheum. 2007 Dec;56(12):4095-103.
Contemporary concepts of inflammation, damage and repair in rheumatic diseases. Luyten FP, Lories RJ, Verschueren P, de Vlam K, Westhovens R. Best Pract Res Clin Rheumatol. 2006 Oct;20(5):829-48.
Noggin haploinsufficiency differentially affects tissue responses in destructive and remodeling arthritis. Lories RJ, Daans M, Derese I, Matthys P, Kasran A, Tylzanowski P, Ceuppens JL, Luyten FP. Arthritis Rheum. 2006 Jun;54(6):1736-46.
Bone morphogenetic protein signaling in joint homeostasis and disease. Lories RJ, Luyten FP. Cytokine Growth Factor Rev. 2005 Jun;16(3):287-98.


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