Work Package 2

Work Package 2

WP 2: Generalisability of genes and biomarkers to various European populations: geographic diversity and environmental risk factors




  1. Investigate the generalisability of the genotyped gene variants across Europe. Investigate the generalisability of the candidate gene variants across the world using Asian cohorts.
  2. Genotyping of osteoarthritis candidate (gene) variants of the different OA populations across Europe.
  3. Assess generalisability of current candidate (gene) variants and discovered variants from WP1 to other qualitative (replacements, meniscal tears, ROA, joint location) and quantitative (COMP, UCTX-II) OA phenotypes.


Own reserach

  • Meulenbelt I, Chapman K, eguez-Gonzalez R, Shi D, Tsezou A, Dai J et al. Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations. Hum Mol Genet 2009; 18(8):1518-23.
  • Chapman K, Takahashi A, Meulenbelt I, Watson C, Rodriguez-Lopez J, Egli R et al. A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5′ UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet 2008; 17(10):1497-504.
  • Meulenbelt I, Min JL, Bos S, Riyazi N, Houwing-Duistermaat JJ, van der Wijk HJ et al. Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet 2008; 17(12):1867-75.
  • Bos SD, Slagboom PE, Meulenbelt I. New insights into osteoarthritis: early developmental features of an ageing-related disease. Curr Opin Rheumatol 2008; 20(5):553-9.
  • Colas F, Meulenbelt I, Houwing-Duistermaat JJ, Kloppenburg M, Watt I, van Rooden SM et al. Reliability of cluster results for different types of time adjustments in complex disease research. Conf Proc IEEE Eng Med Biol Soc 2008; 2008:4601-4.
  • Bos SD, Kloppenburg M, Suchiman E, van BE, Slagboom PE, Meulenbelt I. The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA. Osteoarthritis Cartilage 2009; 17(5):621-6.
  • Bos SD, Suchiman HE, Kloppenburg M, Houwing-Duistermaat JJ, Le Graverand MP, Seymour AB et al. Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study. Ann Rheum Dis 2008; 67(6):877-9.

OA-related research

  • Tufan A, Meulenbelt I, Bijsterbosch J, Kroon HM, Bierma-Zeinstra SM, Nelissen RG et al. Familial influence on tibiofemoral alignment. Ann Rheum Dis 2009.
  • Bijsterbosch J, Visser W, Kroon HM, Stamm T, Meulenbelt I, Huizinga TW et al. Thumb base involvement in symptomatic hand osteoarthritis is associated with more pain and functional disability. Ann Rheum Dis 2009.
  • Botha-Scheepers S, Watt I, Slagboom E, de Craen AJ, Meulenbelt I, Rosendaal FR et al. Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis. Ann Rheum Dis 2008; 67(8):1165-9.

Involved in “the novo” replication

  • Zhai G, van Meurs JB, Livshits G, Meulenbelt I, Valdes AM, Soranzo N et al. A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium. J Med Genet 2009.
  • Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A et al. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum 2009; 60(6):1710-21.
  • Rodriguez-Lopez J, Pombo-Suarez M, Loughlin J, Tsezou A, Blanco FJ, Meulenbelt I et al. Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. Osteoarthritis Cartilage 2009; 17(3):321-7.
  • Dieguez-Gonzalez R, Calaza M, Shi D, Meulenbelt I, Loughlin J, Tsezou A et al. Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections. Ann Rheum Dis 2009; 68(6):1017-21.