Work Package 1
WP 1: Genome Wide Association Studies To Identify OA Risk Genes
To identify, using already funded genome-wide association analyses of several European cohorts and case control collections with OA data:
- Genetic variation (SNPs and CNVs) that is strongly and consistently associated to risk of OA
- The genetic contribution of candidate gene SNPs and SNPs in genes from candidate pathways, to risk of OA by focussed GWA analysis of tagging SNPS for these genes.