Articles
Supplementary material for the article Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis by Valdes and co-workers published in Arthritis and Rheumatism. Download material.Supplementary tables for the article Different risk factors are involved in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes by Valdes and co-workers published in Arthritis and Rheumatism. Download tables.
A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.
Guangju Zhai, Joyce B J van Meurs, Gregory Livshits, Ingrid Meulenbelt, Ana M Valdes, Nicole Soranzo, Deborah Hart, Feng Zhang, Bernet S Kato, Brent Richards, Fran MK Williams, Mike Inouye, Margreet Kloppenburg, Panos Deloukas, Eline Slagboom, Andre Uitterlinden, and Tim D Spector
J Med Genet 2009. Link to article
1st and 2nd reporting periods
1. Valdes AM, Evangelou E, Kerkhof HJM, Tamm A, Doherty SA, Kisand K, Tamm A, Kerna I, uitterlinden A, Hofman A, Rivadeneira F, Cooper C, Dennison EM, Zhang W, Muir KR, Ioannidis JPA, Wheeler M, Maciewicz RA, van Meurs JB, Arden NK, Doherty M, Spector TD. The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genomewide statistical significance. Ann Rheum Dis In Press
2. Evangelou E, Valdes AM, Kerkhof HJ, et al. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis. In press.
3. Jeyabalan J, Nesbit MA, Galvanovskis J, Callaghan R, Rorsman P, Thakker RV. SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1. PLoS One. 2010 May 14;5(5):e10646.
4. Kerkhof HJ, Bierma-Zeinstra SM, Castano-Betancourt MC, de Maat MP, Hofman A, Pols HA, Rivadeneira F, Witteman JC, Uitterlinden AG, van Meurs JB. Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index. Ann Rheum Dis. 2010 Epub ahead of print.
5. Kerkhof HJ, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P, Ingvarsson T, Jhamai M, Jonsson H, Stolk L, Thorleifsson G, Zhai G, Zhang F, Zhu Y, van der Breggen R, Carr A, Doherty M, Doherty S, Felson DT, Gonzalez A, Halldorsson BV, Hart DJ, Hauksson VB, Hofman A, Ioannidis JP, Kloppenburg M, Lane NE, Loughlin J, Luyten FP, Nevitt MC, Parimi N, Pols HA, Rivadeneira F, Slagboom EP, Styrkarsdottir U, Tsezou A, van de Putte T, Zmuda J, Spector TD, Stefansson K, Uitterlinden AG, van Meurs JB. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum. 2010 Feb;62(2):499-510.
6. Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gomez-Reino JJ, Gonzalez A, Halldorsson BV, Hauksson VB, Hofman A, Hart DJ, Ikegawa S, Ingvarsson T, Jiang Q, Jonsdottir I, Jonsson H, Kerkhof HJ, Kloppenburg M, Lane NE, Li J, Lories RJ, van Meurs JB, Nakki A, Nevitt MC, Rodriguez-Lopez J, Shi D, Slagboom PE, Stefansson K, Tsezou A, Wallis GA, Watson CM, Spector TD, Uitterlinden AG, Valdes AM, Ioannidis JP. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum. 2009 Jun;60(6):1710-21.
7. van Meurs JB, Uitterlinden AG, Stolk L, Kerkhof HJ, Hofman A, Pols HA, Bierma-Zeinstra SM. .A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain. Arthritis Rheum. 2009 Feb;60(2):628-9.
8. Lodewyckx L, Lories RJ. WNT Signaling in osteoarthritis and osteoporosis: what is the biological significance for the clinician? Curr Rheumatol Rep. 2009 Feb;11(1):23-30. Review.
9. Luyten FP, Tylzanowski P, Lories RJ. Wnt signaling and osteoarthritis. Bone. 2009 Apr;44(4):522-7.
10. Daans M, Lories RJ, Luyten FP. Absence of GDF5 does not interfere with LPS Toll-like receptor signaling. Clin Exp Rheumatol. 2009 May-Jun;27(3):495-8.
11. Valdes AM, Spector TD, Tamm A, Kisand K, Doherty SA, Dennison EM, Mangino M, Tamm A, Kerna I, Hart DJ, Wheeler M, Cooper C, Lories RJ, Arden NK, Doherty M. Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis Rheum. 2010 Apr 21. [Epub ahead of print]
12. Valdes AM, McWilliams D, Arden NK, Doherty SA, Wheeler M, Muir KR, Zhang W, Cooper C, Maciewicz RA, Doherty M. Different risk factors are involved in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes. Arthritis Rheum. 2010 May 24.
13. Valdes AM, Arden NK, Tamm A, Kisand K, Doherty S, Pola E, Cooper C, Tamm A, Muir KR, Kerna I, Hart D, O'Neil F, Zhang W, Spector TD, Maciewicz RA, Doherty M. A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis. Osteoarthritis Cartilage. 2010 May;18(5):699-704.
14. Valdes AM, Lories RJ, van Meurs JB, Kerkhof H, Doherty S, Hofman A, Hart DJ, Zhang F, Luyten FP, Uitterlinden AG, Doherty M, Spector TD. Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women. Arthritis Rheum. 2009 Jul;60(7):2046-54.
15. Valdes AM, Spector TD, Doherty S, Wheeler M, Hart DJ, Doherty M. Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. Ann Rheum Dis. 2009 Dec;68(12):1916-20.
16. Valdes AM, Loughlin J, Timms KM, van Meurs JJ, Southam L, Wilson SG, Doherty S, Lories RJ, Luyten FP, Gutin A, Abkevich V, Ge D, Hofman A, Uitterlinden AG, Hart DJ, Zhang F, Zhai G, Egli RJ, Doherty M, Lanchbury J, Spector TD. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet. 2008 Jun;82(6):1231-40.
17. Valdes AM, Spector TD. The clinical relevance of genetic susceptibility to osteoarthritis. Best Pract Res Clin Rheumatol. 2010 Feb;24(1):3-14. Review.
18. Valdes AM, Spector TD. The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol. 2010 Mar;22(2):139-43. Review.
19. Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Med Clin North Am. 2009 Jan;93(1):45-66.
20. Zhai G, van Meurs JB, Livshits G, Meulenbelt I, Valdes AM, Soranzo N, Hart D, Zhang F, Kato BS, Richards JB, Williams FM, Inouye M, Kloppenburg M, Deloukas P, Slagboom E, Uitterlinden A, Spector TD. A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium. J Med Genet. 2009 Sep;46(9):614-6.
21. Kerkhof JM, Uitterlinden AG, Valdes AM, Hart DJ, Rivadeneira F, Jhamai M, Hofman A, Pols HA, Bierma-Zeinstra SM, Spector TD, van Meurs JB. Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. Osteoarthritis Cartilage. 2008 Oct;16(10):1141-9.
22. Ana M Valdes, Tim D Spector The Contribution of Genes to Osteoarthritis. Rheumatic Disease Clinics of North America 2008, Volume 34, Issue 3, Pages 581-603.
23. Lories RJ, Peeters J, Szlufcik K, Hespel P, Luyten FP. Deletion of frizzled-related protein reduces voluntary running exercise performance in mice. Osteoarthritis Cartilage. 2009 Mar;17(3):390-6.
24. Lories RJ. Joint homeostasis, restoration, and remodeling in osteoarthritis. Best Pract Res Clin Rheumatol. 2008 Apr;22(2):209-20.
25. Vaes RB, Rivadeneira F, Kerkhof JM, Hofman A, Pols HA, Uitterlinden AG, van Meurs JB. Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study. Ann Rheum Dis. 2009 Nov;68(11):1754-60.
26. Valdes AM, Spector TD. The Genetic Predisposition to Osteoarthritis IBMS BoneKEy. 2009 April;6(4)
27. Valdes AM. Molecular pathogenesis and genetics of osteoarthritis: implications for personalized medicine. Personalized Medicine 2010 7(1):49-63
28. K.B. Van Landuyt, E.A. Jones, D. McGonagle, F.P. Luyten, R.J. Lories. Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis. Arthritis Research and Therapy 2010; 12: R15.
29. R.J. Lories, F.P. Luyten. Osteoimmunology : Wnt antagonists: for better or worse? Nature Reviews Rheumatology 2009; 5(8):420-1