Articles
Supplementary material for the article Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis by Valdes and co-workers published in Arthritis and Rheumatism. Download material.
Supplementary tables for the article Different risk factors are involved in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes by Valdes and co-workers published in Arthritis and Rheumatism. Download tables.
A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.
Guangju Zhai, Joyce B J van Meurs, Gregory Livshits, Ingrid Meulenbelt, Ana M Valdes, Nicole Soranzo, Deborah Hart, Feng Zhang, Bernet S Kato, Brent Richards, Fran MK Williams, Mike Inouye, Margreet Kloppenburg, Panos Deloukas, Eline Slagboom, Andre Uitterlinden, and Tim D Spector
J Med Genet 2009. Link to article
1st and 2nd reporting periods
1. Valdes AM, Evangelou E, Kerkhof HJM, Tamm A, Doherty SA, Kisand K, Tamm A, Kerna I, uitterlinden A, Hofman A, Rivadeneira F, Cooper C, Dennison EM, Zhang W, Muir KR, Ioannidis JPA, Wheeler M, Maciewicz RA, van Meurs JB, Arden NK, Doherty M, Spector TD. The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genomewide statistical significance. Ann Rheum Dis Epub ahead of print
PubMed link
2. Evangelou E, Valdes AM, Kerkhof HJ, et al. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis. In press.
3. Jeyabalan J, Nesbit MA, Galvanovskis J, Callaghan R, Rorsman P, Thakker RV. SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1. PLoS One. 2010 May 14;5(5):e10646.PubMed link
4. Kerkhof HJ, Bierma-Zeinstra SM, Castano-Betancourt MC, de Maat MP, Hofman A, Pols HA, Rivadeneira F, Witteman JC, Uitterlinden AG, van Meurs JB. Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index. Ann Rheum Dis. 2010 Epub ahead of print.PubMed link
5. Kerkhof HJ, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P, Ingvarsson T, Jhamai M, Jonsson H, Stolk L, Thorleifsson G, Zhai G, Zhang F, Zhu Y, van der Breggen R, Carr A, Doherty M, Doherty S, Felson DT, Gonzalez A, Halldorsson BV, Hart DJ, Hauksson VB, Hofman A, Ioannidis JP, Kloppenburg M, Lane NE, Loughlin J, Luyten FP, Nevitt MC, Parimi N, Pols HA, Rivadeneira F, Slagboom EP, Styrkarsdottir U, Tsezou A, van de Putte T, Zmuda J, Spector TD, Stefansson K, Uitterlinden AG, van Meurs JB. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum. 2010 Feb;62(2):499-510.PubMed link
6. Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gomez-Reino JJ, Gonzalez A, Halldorsson BV, Hauksson VB, Hofman A, Hart DJ, Ikegawa S, Ingvarsson T, Jiang Q, Jonsdottir I, Jonsson H, Kerkhof HJ, Kloppenburg M, Lane NE, Li J, Lories RJ, van Meurs JB, Nakki A, Nevitt MC, Rodriguez-Lopez J, Shi D, Slagboom PE, Stefansson K, Tsezou A, Wallis GA, Watson CM, Spector TD, Uitterlinden AG, Valdes AM, Ioannidis JP. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum. 2009 Jun;60(6):1710-21.PubMed link
7. van Meurs JB, Uitterlinden AG, Stolk L, Kerkhof HJ, Hofman A, Pols HA, Bierma-Zeinstra SM.A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain. Arthritis Rheum. 2009 Feb;60(2):628-9.PubMed link
8. Lodewyckx L, Lories RJ. WNT Signaling in osteoarthritis and osteoporosis: what is the biological significance for the clinician? Curr Rheumatol Rep. 2009 Feb;11(1):23-30. Review.PubMed link
9. Luyten FP, Tylzanowski P, Lories RJ. Wnt signaling and osteoarthritis. Bone. 2009 Apr;44(4):522-7.PubMed link
10. Daans M, Lories RJ, Luyten FP. Absence of GDF5 does not interfere with LPS Toll-like receptor signaling. Clin Exp Rheumatol. 2009 May-Jun;27(3):495-8.PubMed link
11. Valdes AM, Spector TD, Tamm A, Kisand K, Doherty SA, Dennison EM, Mangino M, Tamm A, Kerna I, Hart DJ, Wheeler M, Cooper C, Lories RJ, Arden NK, Doherty M. Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis Rheum. 2010 Apr 21. [Epub ahead of print]PubMed link
12. Valdes AM, McWilliams D, Arden NK, Doherty SA, Wheeler M, Muir KR, Zhang W, Cooper C, Maciewicz RA, Doherty M. Different risk factors are involved in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes. Arthritis Rheum. 2010 May 24.PubMed link
13. Valdes AM, Arden NK, Tamm A, Kisand K, Doherty S, Pola E, Cooper C, Tamm A, Muir KR, Kerna I, Hart D, O'Neil F, Zhang W, Spector TD, Maciewicz RA, Doherty M. A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis. Osteoarthritis Cartilage. 2010 May;18(5):699-704.PubMed link
14. Valdes AM, Lories RJ, van Meurs JB, Kerkhof H, Doherty S, Hofman A, Hart DJ, Zhang F, Luyten FP, Uitterlinden AG, Doherty M, Spector TD. Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women. Arthritis Rheum. 2009 Jul;60(7):2046-54.PubMed link
15. Valdes AM, Spector TD, Doherty S, Wheeler M, Hart DJ, Doherty M. Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. Ann Rheum Dis. 2009 Dec;68(12):1916-20.PubMed link
16. Valdes AM, Loughlin J, Timms KM, van Meurs JJ, Southam L, Wilson SG, Doherty S, Lories RJ, Luyten FP, Gutin A, Abkevich V, Ge D, Hofman A, Uitterlinden AG, Hart DJ, Zhang F, Zhai G, Egli RJ, Doherty M, Lanchbury J, Spector TD. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet. 2008 Jun;82(6):1231-40.PubMed link
17. Valdes AM, Spector TD. The clinical relevance of genetic susceptibility to osteoarthritis. Best Pract Res Clin Rheumatol. 2010 Feb;24(1):3-14. Review.PubMed link
18. Valdes AM, Spector TD. The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol. 2010 Mar;22(2):139-43. Review.PubMed link
19. Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Med Clin North Am. 2009 Jan;93(1):45-66.PubMed link
20. Zhai G, van Meurs JB, Livshits G, Meulenbelt I, Valdes AM, Soranzo N, Hart D, Zhang F, Kato BS, Richards JB, Williams FM, Inouye M, Kloppenburg M, Deloukas P, Slagboom E, Uitterlinden A, Spector TD. A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium. J Med Genet. 2009 Sep;46(9):614-6.PubMed link
21. Kerkhof JM, Uitterlinden AG, Valdes AM, Hart DJ, Rivadeneira F, Jhamai M, Hofman A, Pols HA, Bierma-Zeinstra SM, Spector TD, van Meurs JB. Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. Osteoarthritis Cartilage. 2008 Oct;16(10):1141-9.PubMed link
22. Ana M Valdes, Tim D Spector The Contribution of Genes to Osteoarthritis. Rheumatic Disease Clinics of North America 2008, Volume 34, Issue 3, Pages 581-603.PubMed link
23. Lories RJ, Peeters J, Szlufcik K, Hespel P, Luyten FP. Deletion of frizzled-related protein reduces voluntary running exercise performance in mice. Osteoarthritis Cartilage. 2009 Mar;17(3):390-6.PubMed link
24. Lories RJ. Joint homeostasis, restoration, and remodeling in osteoarthritis. Best Pract Res Clin Rheumatol. 2008 Apr;22(2):209-20.PubMed link
25. Vaes RB, Rivadeneira F, Kerkhof JM, Hofman A, Pols HA, Uitterlinden AG, van Meurs JB. Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study. Ann Rheum Dis. 2009 Nov;68(11):1754-60.PubMed link
26. Valdes AM, Spector TD. The Genetic Predisposition to Osteoarthritis IBMS BoneKEy. 2009 April;6(4)
27. Valdes AM. Molecular pathogenesis and genetics of osteoarthritis: implications for personalized medicine. Personalized Medicine 2010 7(1):49-63
28. K.B. Van Landuyt, E.A. Jones, D. McGonagle, F.P. Luyten, R.J. Lories. Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis. Arthritis Research and Therapy 2010; 12: R15.PubMed link
29. R.J. Lories, F.P. Luyten.Osteoimmunology : Wnt antagonists: for better or worse? Nature Reviews Rheumatology 2009; 5(8):420-1
3rd reporting period
30. Valdes AM, Arden NK, Vaughn FL, Doherty SA, Leaverton PE, Zhang W, Muir KR, Rampersaud E, Dennison EM, Edwards MH, Jameson KA, Javaid MK, Spector TD, Cooper C, Maciewicz RA, Doherty M.Role of the Na(V)1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain. Arthritis Care Res (Hoboken). 2010 Oct 28. [Epub ahead of print]PubMed link31. Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM, Carr A, Cooper C, Dai J, Doherty M, Doherty SA, Felson D, Gonzalez A, Gordon A, Harilainen A, Hart DJ, Hauksson VB, Heliovaara M, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Jonsdottir I, Kawaguchi H, Kloppenburg M, Kujala UM, Lane NE, Leino-Arjas P, Lohmander LS, Luyten FP, Malizos KN, Nakajima M, Nevitt MC, Pols HA, Rivadeneira F, Shi D, Slagboom E, Spector TD, Stefansson K, Sudo A, Tamm A, Tamm AE, Tsezou A, Uchida A, Uitterlinden AG, Wilkinson JM, Yoshimura N, Valdes AM, van Meurs JB.Recommendations For Standardization And Phenotype Definitions In Genetic Studies Of Osteoarthritis: The TREAT-OA Consortium.Osteoarthritis Cartilage. 2010 Nov 5. [Epub ahead of print] PubMed link 32.Kerkhof HJ, Doherty M, Arden NK, Abramson SB, Attur M, Bos SD, Cooper C, Dennison EM, Doherty SA, Evangelou E, Hart DJ, Hofman A, Javaid K, Kerna I, Kisand K, Kloppenburg M, Krasnokutsky S, Maciewicz RA, Meulenbelt I, Muir KR, Rivadeneira F, Samuels J, Sezgin M, Slagboom E, Smith AJ, Spector TD, Tamm A, Tamm A, Uitterlinden AG, Wheeler M, Zhai G, Zhang W, van Meurs JB, Valdes AM. Large scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis.Osteoarthritis Cartilage 2010 Dec 9. [Epub ahead of print]PMID: 21146623 PubMed link
33.Williams F, Popham M, Hart D, de Schepper E, Bierma-Zeinstra S, Hofman A, Uitterlinden AG, Arden N, Cooper C, Spector T, Valdes A, van Meurs J.GDF5 SNP rs143383 is associated with lumbar disc disease in northern European women. Arthritis Rheum. 2010 Dec 2. [Epub ahead of print]PMID: 21128259 PubMed linkRelated citations
34.Kerkhof HJ, Meulenbelt I, Carr A, Gonzalez A, Hart D, Hofman A, Kloppenburg M, Lane NE, Loughlin J, Nevitt MC, Pols HA, Rivadeneira F, Slagboom EP, Spector TD, Stolk L, Tsezou A, Uitterlinden AG, Valdes AM, van Meurs JB.Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis.BMC Med Genet. 2010 Nov 16;11:164.PMID: 21080949 PubMed linkFree PMC ArticleFree textRelated citations
35.Valdes AM, Spector TD.Genetic epidemiology of hip and knee osteoarthritis.Nat Rev Rheumatol. 2010 Nov 16. [Epub ahead of print]PMID: 21079645 PubMed link
36.Valdes AM.Involvement of the CLEC3B gene in osteoarthritis.Osteoarthritis Cartilage. 2010 Nov 12. [Epub ahead of print] No abstract available. PMID: 21075210 PubMed link
37.Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories RJ, Karassa FB, Tylzanowski P, Bos SD; arcOGEN Consortium, Akune T, Arden NK, Carr A, Chapman K, Cupples LA, Dai J, Deloukas P, Doherty M, Doherty S, Engstrom G, Gonzalez A, Halldorsson BV, Hammond CL, Hart DJ, Helgadottir H, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Kaprio J, Kawaguchi H, Kisand K, Kloppenburg M, Kujala UM, Lohmander LS, Loughlin J, Luyten FP, Mabuchi A, McCaskie A, Nakajima M, Nilsson PM, Nishida N, Ollier WE, Panoutsopoulou K, van de Putte T, Ralston SH, Rivadeneira F, Saarela J, Schulte-Merker S, Shi D, Slagboom PE, Sudo A, Tamm A, Tamm A, Thorleifsson G, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Yoshimura N, Zeggini E, Zhai G, Zhang F, Jonsdottir I, Uitterlinden AG, Felson DT, van Meurs JB, Stefansson K, Ioannidis JP, Spector TD;Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA). Ann Rheum Dis. 2010 Nov 10. [Epub ahead of print]PMID: 21068099 PubMed link
38.Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM, Carr A, Cooper C, Dai J, Doherty M, Doherty SA, Felson D, Gonzalez A, Gordon A, Harilainen A, Hart DJ, Hauksson VB, Heliovaara M, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Jonsdottir I, Kawaguchi H, Kloppenburg M, Kujala UM, Lane NE, Leino-Arjas P, Lohmander LS, Luyten FP, Malizos KN, Nakajima M, Nevitt MC, Pols HA, Rivadeneira F, Shi D, Slagboom E, Spector TD, Stefansson K, Sudo A, Tamm A, Tamm AE, Tsezou A, Uchida A, Uitterlinden AG, Wilkinson JM, Yoshimura N, Valdes AM, van Meurs JB. Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage. 2010 Nov 6. [Epub ahead of print]PMID: 21059398 PubMed link
39.Valdes AM, Arden NK, Vaughn FL, Doherty SA, Leaverton PE, Zhang W, Muir KR, Rampersaud E, Dennison EM, Edwards MH, Jameson KA, Javaid MK, Spector TD, Cooper C, Maciewicz RA, Doherty M.Role of the Na(V)1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain.Arthritis Care Res (Hoboken). 2010 Oct 28. [Epub ahead of print]PMID: 21031562 PubMed link
40.Valdes AM, Evangelou E, Kerkhof HJ, Tamm A, Doherty SA, Kisand K, Tamm A, Kerna I, Uitterlinden A, Hofman A, Rivadeneira F, Cooper C, Dennison EM, Zhang W, Muir KR, Ioannidis JP, Wheeler M, Maciewicz RA, van Meurs JB, Arden NK, Spector TD, Doherty M.The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance.Ann Rheum Dis. 2010 Sep 24. [Epub ahead of print] No abstract available. PMID: 20870806 PubMed link
41.Ana M Valdes, Gert De Wilde, Sally A Doherty, Rik J Lories, Frances L Vaughn, Laura L Laslett, Rose A Maciewicz, Anushka Soni, Deborah J Hart, Weiya Zhang, Kenneth R Muir, Elaine M Dennison, Margaret Wheeler, Paul Leaverton, Cyrus Cooper, Tim D Spector, Flavia M Cicuttini, Victoria Chapman, Graeme Jones, Nigel K Arden, Michael Doherty The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.ARD Online First,May 25, 2011 [Epub ahead of print] 10.1136/ard.2010.148122link
42.Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Kerkhof HJ, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Loughlin J, McCaskie A, Ollier WE, Ralston SH, Spector TD, Wallis GA, Wilkinson JM, Aslam N, Birell F, Carluke I, Joseph J, Rai A, Reed M, Walker K; arcOGEN Consortium, Doherty SA, Jonsdottir I, Maciewicz RA, Muir KR, Metspalu A, Rivadeneira F, Stefansson K, Styrkarsdottir U, Uitterlinden AG, van Meurs JB, Zhang W, Valdes AM, Doherty M, Zeggini E.A Variant in MCF2L Is Associated with Osteoarthritis. Am J Hum Genet. Sep 9, 2011;89(3):446-50. Epub 2011 Aug 25.PubMed link
43.Valdes AM, Doherty SA, Zhang W, Muir KR, Maciewicz RA, Doherty M.Inverse Relationship Between Preoperative Radiographic Severity and Postoperative Pain in Patients with Osteoarthritis who Have Undergone Total Joint Arthroplasty. Semin Arthritis Rheum.Aug 23, 2011 [Epub ahead of print] PMID: 21868060 PubMed link Related Citations
44.Valdes AM, Styrkarsdottir U, Doherty M, Morris DL, Mangino M, Tamm A, Doherty SA, Kisand K, Kerna I, Tamm A, Wheeler M, Maciewicz RA, Zhang W, Muir KR, Dennison EM, Hart DJ, Metrustry S, Jonsdottir I, Jonsson GF, Jonsson H, Ingvarsson T, Cooper C, Vyse TJ, Spector TD, Stefansson K, Arden NK.Large Scale Replication Study of the Association between HLA Class II/BTNL2 Variants and Osteoarthritis of the Knee in European-Descent Populations. PLoS One. 2011;6(8):e23371. Epub 2011 Aug 10.PMID:21853121 PubMed link ---------- <----------------------------------------------------------