Articles

Articles

Publications

2013

Supplementary material for the article Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis by Valdes and co-workers published in Arthritis and Rheumatism. Download material.

Supplementary tables for the article Different risk factors are involved in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes by Valdes and co-workers published in Arthritis and Rheumatism. Download tables.

A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.
Guangju Zhai, Joyce B J van Meurs, Gregory Livshits, Ingrid Meulenbelt, Ana M Valdes, Nicole Soranzo, Deborah Hart, Feng Zhang, Bernet S Kato, Brent Richards, Fran MK Williams, Mike Inouye, Margreet Kloppenburg, Panos Deloukas, Eline Slagboom, Andre Uitterlinden, and Tim D Spector
J Med Genet 2009. Link to article

 

1st and 2nd reporting periods

1. Valdes AM, Evangelou E, Kerkhof HJM, Tamm A, Doherty SA, Kisand K, Tamm A, Kerna I, uitterlinden A, Hofman A, Rivadeneira F, Cooper C, Dennison EM, Zhang W, Muir KR, Ioannidis JPA, Wheeler M, Maciewicz RA, van Meurs JB, Arden NK, Doherty M, Spector TD. The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genomewide statistical significance. Ann Rheum Dis Epub ahead of print
PubMed link

2. Evangelou E, Valdes AM, Kerkhof HJ, et al. Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis. In press.

3. Jeyabalan J, Nesbit MA, Galvanovskis J, Callaghan R, Rorsman P, Thakker RV. SEDLIN forms homodimers: characterisation of SEDLIN mutations and their interactions with transcription factors MBP1, PITX1 and SF1. PLoS One. 2010 May 14;5(5):e10646.PubMed link

4. Kerkhof HJ, Bierma-Zeinstra SM, Castano-Betancourt MC, de Maat MP, Hofman A, Pols HA, Rivadeneira F, Witteman JC, Uitterlinden AG, van Meurs JB. Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index. Ann Rheum Dis. 2010 Epub ahead of print.PubMed link

5. Kerkhof HJ, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P, Ingvarsson T, Jhamai M, Jonsson H, Stolk L, Thorleifsson G, Zhai G, Zhang F, Zhu Y, van der Breggen R, Carr A, Doherty M, Doherty S, Felson DT, Gonzalez A, Halldorsson BV, Hart DJ, Hauksson VB, Hofman A, Ioannidis JP, Kloppenburg M, Lane NE, Loughlin J, Luyten FP, Nevitt MC, Parimi N, Pols HA, Rivadeneira F, Slagboom EP, Styrkarsdottir U, Tsezou A, van de Putte T, Zmuda J, Spector TD, Stefansson K, Uitterlinden AG, van Meurs JB. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum. 2010 Feb;62(2):499-510.PubMed link

6. Evangelou E, Chapman K, Meulenbelt I, Karassa FB, Loughlin J, Carr A, Doherty M, Doherty S, Gomez-Reino JJ, Gonzalez A, Halldorsson BV, Hauksson VB, Hofman A, Hart DJ, Ikegawa S, Ingvarsson T, Jiang Q, Jonsdottir I, Jonsson H, Kerkhof HJ, Kloppenburg M, Lane NE, Li J, Lories RJ, van Meurs JB, Nakki A, Nevitt MC, Rodriguez-Lopez J, Shi D, Slagboom PE, Stefansson K, Tsezou A, Wallis GA, Watson CM, Spector TD, Uitterlinden AG, Valdes AM, Ioannidis JP. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum. 2009 Jun;60(6):1710-21.PubMed link

7. van Meurs JB, Uitterlinden AG, Stolk L, Kerkhof HJ, Hofman A, Pols HA, Bierma-Zeinstra SM.A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain.Arthritis Rheum. 2009 Feb;60(2):628-9.PubMed link

8. Lodewyckx L, Lories RJ. WNT Signaling in osteoarthritis and osteoporosis: what is the biological significance for the clinician? Curr Rheumatol Rep. 2009 Feb;11(1):23-30. Review.PubMed link

9. Luyten FP, Tylzanowski P, Lories RJ. Wnt signaling and osteoarthritis. Bone. 2009 Apr;44(4):522-7.PubMed link

10. Daans M, Lories RJ, Luyten FP. Absence of GDF5 does not interfere with LPS Toll-like receptor signaling. Clin Exp Rheumatol. 2009 May-Jun;27(3):495-8.PubMed link

11. Valdes AM, Spector TD, Tamm A, Kisand K, Doherty SA, Dennison EM, Mangino M, Tamm A, Kerna I, Hart DJ, Wheeler M, Cooper C, Lories RJ, Arden NK, Doherty M. Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis Rheum. 2010 Apr 21. [Epub ahead of print]PubMed link

12. Valdes AM, McWilliams D, Arden NK, Doherty SA, Wheeler M, Muir KR, Zhang W, Cooper C, Maciewicz RA, Doherty M. Different risk factors are involved in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes. Arthritis Rheum. 2010 May 24.PubMed link

13. Valdes AM, Arden NK, Tamm A, Kisand K, Doherty S, Pola E, Cooper C, Tamm A, Muir KR, Kerna I, Hart D, O’Neil F, Zhang W, Spector TD, Maciewicz RA, Doherty M. A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis. Osteoarthritis Cartilage. 2010 May;18(5):699-704.PubMed link

14. Valdes AM, Lories RJ, van Meurs JB, Kerkhof H, Doherty S, Hofman A, Hart DJ, Zhang F, Luyten FP, Uitterlinden AG, Doherty M, Spector TD. Variation at the ANP32A gene is associated with risk of hip osteoarthritis in women. Arthritis Rheum. 2009 Jul;60(7):2046-54.PubMed link

15. Valdes AM, Spector TD, Doherty S, Wheeler M, Hart DJ, Doherty M. Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations. Ann Rheum Dis. 2009 Dec;68(12):1916-20.PubMed link

16. Valdes AM, Loughlin J, Timms KM, van Meurs JJ, Southam L, Wilson SG, Doherty S, Lories RJ, Luyten FP, Gutin A, Abkevich V, Ge D, Hofman A, Uitterlinden AG, Hart DJ, Zhang F, Zhai G, Egli RJ, Doherty M, Lanchbury J, Spector TD. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet. 2008 Jun;82(6):1231-40.PubMed link

17. Valdes AM, Spector TD. The clinical relevance of genetic susceptibility to osteoarthritis. Best Pract Res Clin Rheumatol. 2010 Feb;24(1):3-14. Review.PubMed link

18. Valdes AM, Spector TD. The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol. 2010 Mar;22(2):139-43. Review.PubMed link

19. Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Med Clin North Am. 2009 Jan;93(1):45-66.PubMed link

20. Zhai G, van Meurs JB, Livshits G, Meulenbelt I, Valdes AM, Soranzo N, Hart D, Zhang F, Kato BS, Richards JB, Williams FM, Inouye M, Kloppenburg M, Deloukas P, Slagboom E, Uitterlinden A, Spector TD. A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium. J Med Genet. 2009 Sep;46(9):614-6.PubMed link

21. Kerkhof JM, Uitterlinden AG, Valdes AM, Hart DJ, Rivadeneira F, Jhamai M, Hofman A, Pols HA, Bierma-Zeinstra SM, Spector TD, van Meurs JB. Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts. Osteoarthritis Cartilage. 2008 Oct;16(10):1141-9.PubMed link

22. Ana M Valdes, Tim D Spector The Contribution of Genes to Osteoarthritis. Rheumatic Disease Clinics of North America 2008, Volume 34, Issue 3, Pages 581-603.PubMed link

23. Lories RJ, Peeters J, Szlufcik K, Hespel P, Luyten FP. Deletion of frizzled-related protein reduces voluntary running exercise performance in mice. Osteoarthritis Cartilage. 2009 Mar;17(3):390-6.PubMed link

24. Lories RJ. Joint homeostasis, restoration, and remodeling in osteoarthritis. Best Pract Res Clin Rheumatol. 2008 Apr;22(2):209-20.PubMed link

25. Vaes RB, Rivadeneira F, Kerkhof JM, Hofman A, Pols HA, Uitterlinden AG, van Meurs JB. Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study. Ann Rheum Dis. 2009 Nov;68(11):1754-60.PubMed link

26. Valdes AM, Spector TD. The Genetic Predisposition to Osteoarthritis IBMS BoneKEy. 2009 April;6(4)

27. Valdes AM. Molecular pathogenesis and genetics of osteoarthritis: implications for personalized medicine. Personalized Medicine 2010 7(1):49-63

28. K.B. Van Landuyt, E.A. Jones, D. McGonagle, F.P. Luyten, R.J. Lories. Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis. Arthritis Research and Therapy 2010; 12: R15.PubMed link

29. R.J. Lories, F.P. Luyten.Osteoimmunology : Wnt antagonists: for better or worse? Nature Reviews Rheumatology 2009; 5(8):420-1

3rd reporting period

30. Valdes AM, Arden NK, Vaughn FL, Doherty SA, Leaverton PE, Zhang W, Muir KR, Rampersaud E, Dennison EM, Edwards MH, Jameson KA, Javaid MK, Spector TD, Cooper C, Maciewicz RA, Doherty M.Role of the Na(V)1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain. Arthritis Care Res (Hoboken). 2010 Oct 28. [Epub ahead of print]PubMed link

31. Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM, Carr A, Cooper C, Dai J, Doherty M, Doherty SA, Felson D, Gonzalez A, Gordon A, Harilainen A, Hart DJ, Hauksson VB, Heliovaara M, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Jonsdottir I, Kawaguchi H, Kloppenburg M, Kujala UM, Lane NE, Leino-Arjas P, Lohmander LS, Luyten FP, Malizos KN, Nakajima M, Nevitt MC, Pols HA, Rivadeneira F, Shi D, Slagboom E, Spector TD, Stefansson K, Sudo A, Tamm A, Tamm AE, Tsezou A, Uchida A, Uitterlinden AG, Wilkinson JM, Yoshimura N, Valdes AM, van Meurs JB.Recommendations For Standardization And Phenotype Definitions In Genetic Studies Of Osteoarthritis: The TREAT-OA Consortium.Osteoarthritis Cartilage. 2010 Nov 5. [Epub ahead of print]PubMed link

32.Kerkhof HJ, Doherty M, Arden NK, Abramson SB, Attur M, Bos SD, Cooper C, Dennison EM, Doherty SA, Evangelou E, Hart DJ, Hofman A, Javaid K, Kerna I, Kisand K, Kloppenburg M, Krasnokutsky S, Maciewicz RA, Meulenbelt I, Muir KR, Rivadeneira F, Samuels J, Sezgin M, Slagboom E, Smith AJ, Spector TD, Tamm A, Tamm A, Uitterlinden AG, Wheeler M, Zhai G, Zhang W, van Meurs JB, Valdes AM. Large scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis.Osteoarthritis Cartilage 2010 Dec 9. [Epub ahead of print]PMID: 21146623 PubMed link

33.Williams F, Popham M, Hart D, de Schepper E, Bierma-Zeinstra S, Hofman A, Uitterlinden AG, Arden N, Cooper C, Spector T, Valdes A, van Meurs J.GDF5 SNP rs143383 is associated with lumbar disc disease in northern European women. Arthritis Rheum. 2010 Dec 2. [Epub ahead of print]PMID: 21128259 PubMed linkRelated citations

34.Kerkhof HJ, Meulenbelt I, Carr A, Gonzalez A, Hart D, Hofman A, Kloppenburg M, Lane NE, Loughlin J, Nevitt MC, Pols HA, Rivadeneira F, Slagboom EP, Spector TD, Stolk L, Tsezou A, Uitterlinden AG, Valdes AM, van Meurs JB.Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis.BMC Med Genet. 2010 Nov 16;11:164.PMID: 21080949 PubMed linkFree PMC ArticleFree textRelated citations

35.Valdes AM, Spector TD.Genetic epidemiology of hip and knee osteoarthritis.Nat Rev Rheumatol. 2010 Nov 16. [Epub ahead of print]PMID: 21079645 PubMed link

36.Valdes AM.Involvement of the CLEC3B gene in osteoarthritis.Osteoarthritis Cartilage. 2010 Nov 12. [Epub ahead of print] No abstract available. PMID: 21075210 PubMed link

37.Evangelou E, Valdes AM, Kerkhof HJ, Styrkarsdottir U, Zhu Y, Meulenbelt I, Lories RJ, Karassa FB, Tylzanowski P, Bos SD; arcOGEN Consortium, Akune T, Arden NK, Carr A, Chapman K, Cupples LA, Dai J, Deloukas P, Doherty M, Doherty S, Engstrom G, Gonzalez A, Halldorsson BV, Hammond CL, Hart DJ, Helgadottir H, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Kaprio J, Kawaguchi H, Kisand K, Kloppenburg M, Kujala UM, Lohmander LS, Loughlin J, Luyten FP, Mabuchi A, McCaskie A, Nakajima M, Nilsson PM, Nishida N, Ollier WE, Panoutsopoulou K, van de Putte T, Ralston SH, Rivadeneira F, Saarela J, Schulte-Merker S, Shi D, Slagboom PE, Sudo A, Tamm A, Tamm A, Thorleifsson G, Thorsteinsdottir U, Tsezou A, Wallis GA, Wilkinson JM, Yoshimura N, Zeggini E, Zhai G, Zhang F, Jonsdottir I, Uitterlinden AG, Felson DT, van Meurs JB, Stefansson K, Ioannidis JP, Spector TD;Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Translation Research in Europe Applied Technologies for Osteoarthritis (TreatOA). Ann Rheum Dis. 2010 Nov 10. [Epub ahead of print]PMID: 21068099PubMed link

38.Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM, Carr A, Cooper C, Dai J, Doherty M, Doherty SA, Felson D, Gonzalez A, Gordon A, Harilainen A, Hart DJ, Hauksson VB, Heliovaara M, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Jonsdottir I, Kawaguchi H, Kloppenburg M, Kujala UM, Lane NE, Leino-Arjas P, Lohmander LS, Luyten FP, Malizos KN, Nakajima M, Nevitt MC, Pols HA, Rivadeneira F, Shi D, Slagboom E, Spector TD, Stefansson K, Sudo A, Tamm A, Tamm AE, Tsezou A, Uchida A, Uitterlinden AG, Wilkinson JM, Yoshimura N, Valdes AM, van Meurs JB. Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium. Osteoarthritis Cartilage. 2010 Nov 6. [Epub ahead of print]PMID: 21059398 PubMed link

39.Valdes AM, Arden NK, Vaughn FL, Doherty SA, Leaverton PE, Zhang W, Muir KR, Rampersaud E, Dennison EM, Edwards MH, Jameson KA, Javaid MK, Spector TD, Cooper C, Maciewicz RA, Doherty M.Role of the Na(V)1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain.Arthritis Care Res (Hoboken). 2010 Oct 28. [Epub ahead of print]PMID: 21031562 PubMed link

40.Valdes AM, Evangelou E, Kerkhof HJ, Tamm A, Doherty SA, Kisand K, Tamm A, Kerna I, Uitterlinden A, Hofman A, Rivadeneira F, Cooper C, Dennison EM, Zhang W, Muir KR, Ioannidis JP, Wheeler M, Maciewicz RA, van Meurs JB, Arden NK, Spector TD, Doherty M.The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance.Ann Rheum Dis. 2010 Sep 24. [Epub ahead of print] No abstract available. PMID: 20870806 PubMed link

41.Ana M Valdes, Gert De Wilde, Sally A Doherty, Rik J Lories, Frances L Vaughn, Laura L Laslett, Rose A Maciewicz, Anushka Soni, Deborah J Hart, Weiya Zhang, Kenneth R Muir, Elaine M Dennison, Margaret Wheeler, Paul Leaverton, Cyrus Cooper, Tim D Spector, Flavia M Cicuttini, Victoria Chapman, Graeme Jones, Nigel K Arden, Michael Doherty The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.ARD Online First,May 25, 2011 [Epub ahead of print] 10.1136/ard.2010.148122link

42.Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Kerkhof HJ, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Loughlin J, McCaskie A, Ollier WE, Ralston SH, Spector TD, Wallis GA, Wilkinson JM, Aslam N, Birell F, Carluke I, Joseph J, Rai A, Reed M, Walker K; arcOGEN Consortium, Doherty SA, Jonsdottir I, Maciewicz RA, Muir KR, Metspalu A, Rivadeneira F, Stefansson K, Styrkarsdottir U, Uitterlinden AG, van Meurs JB, Zhang W, Valdes AM, Doherty M, Zeggini E.A Variant in MCF2L Is Associated with Osteoarthritis. Am J Hum Genet. Sep 9, 2011;89(3):446-50. Epub 2011 Aug 25.PubMed link

43.Valdes AM, Doherty SA, Zhang W, Muir KR, Maciewicz RA, Doherty M.Inverse Relationship Between Preoperative Radiographic Severity and Postoperative Pain in Patients with Osteoarthritis who Have Undergone Total Joint Arthroplasty. Semin Arthritis Rheum.Aug 23, 2011 [Epub ahead of print] PMID: 21868060 PubMed link Related Citations

44.Valdes AM, Styrkarsdottir U, Doherty M, Morris DL, Mangino M, Tamm A, Doherty SA, Kisand K, Kerna I, Tamm A, Wheeler M, Maciewicz RA, Zhang W, Muir KR, Dennison EM, Hart DJ, Metrustry S, Jonsdottir I, Jonsson GF, Jonsson H, Ingvarsson T, Cooper C, Vyse TJ, Spector TD, Stefansson K, Arden NK.Large Scale Replication Study of the Association between HLA Class II/BTNL2 Variants and Osteoarthritis of the Knee in European-Descent Populations. PLoS One. 2011;6(8):e23371. Epub 2011 Aug 10.PMID:21853121 PubMed link

45.Lories RChanging the outcome of osteoarthritis: still a challenge for COX2 inhibitors Arthritis and Rheumatism2011 Sep 8. doi: 10.1002/art.33330. [Epub ahead of print] PMID:21905013 PubMEd link

 

4th Reporting Period

 

46.Cornelis F, Luyten F, Lories R Functional effects of susceptibility genes in osteoarthritis Discovery Medicine 2011; 12(63):129-139 PMID:21878190PubMed link

47.Lodewyckx L, Cailotto F, Thysen S, Luyten FP, Lories R. Tight regulation of wingless-type signalling in the articular cartilage – subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice Arthritis Research and Therapy 2012.Jan 20;14(1):R16. PubMed PMID: 22264237; PubMed Central PMCID: PMC3392806.PubMed link

48.Lodewyckx L, Luyten FP, Lories RJ.  Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis. Rheumatology (Oxford). 2012 Jul 31. [Epub ahead of print] PubMed PMID: 22850184.PubMed link

49.Casta�o Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FM, Doherty SA, Hart DJ, Hofman A, Luyten FP, Maciewicz RA, Mangino M, Metrustry S, Muir K, Peters MJ, Rivadeneira F, Wheeler M, Zhang W, Arden N, Spector TD, Uitterlinden AG, Doherty M, Lories RJ, Valdes AM, van Meurs JB. Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.  Proc Natl Acad Sci U S A. 2012 May 22;109(21):8218-23. Epub 2012 May 7. PubMed PMID: 22566624; PubMed Central PMCID: PMC3361426.PubMed link

50.Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Elliott KS, Chapman K, Day-Williams A, Panoutsopoulou K, Southam L, Lindgren CM; the GIANT consortium, Arden N, Aslam N, Birrell F, Carluke I, Carr A, Deloukas P, Doherty M, Loughlin J, McCaskie A, Ollier WE, Rai A, Ralston S, Reed MR, Spector TD, Valdes AM, Wallis GA, Wilkinson M; the arcOGEN consortium, Zeggini E. Ann Rheum Dis. 2012 Sep 6. [Epub ahead of print] PMID: 22956599 [PubMed - as supplied by publisher]PubMed link

51.Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. arcOGEN Consortium and arcOGEN Collaborators. Lancet. 2012 Sep 1;380(9844):815-23. Epub 2012 Jul 3. PMID: 22763110 [PubMed - in process]PubMed linkRelated citations

52. Genetic contribution to radiographic severity in osteoarthritis of the knee. Valdes AM, Doherty S, Muir KR, Zhang W, Maciewicz RA, Wheeler M, Arden N, Cooper C, Doherty M. Ann Rheum Dis. 2012 Sep;71(9):1537-40. Epub 2012 May 21. PMID: 22615457 [PubMed - in process] Free PMC ArticlePubMed link Related citations

53. Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. Casta�o Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FM, Doherty SA, Hart DJ, Hofman A, Luyten FP, Maciewicz RA, Mangino M, Metrustry S, Muir K, Peters MJ, Rivadeneira F, Wheeler M, Zhang W, Arden N, Spector TD, Uitterlinden AG, Doherty M, Lories RJ, Valdes AM, van Meurs JB. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8218-23. Epub 2012 May 7. PMID: 22566624 [PubMed - indexed for MEDLINE]PubMed link Related citations

54. A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype. Malfait AM, Seymour AB, Gao F, Tortorella MD, Le Graverand-Gastineau MP, Wood LS, Doherty M, Doherty S, Zhang W, Arden NK, Vaughn FL, Leaverton PE, Spector TD, Hart DJ, Maciewicz RA, Muir KR, Das R, Sorge RE, Sotocinal SG, Schorscher-Petcu A, Valdes AM, Mogil JS. Ann Rheum Dis. 2012 Jun;71(6):1042-8. Epub 2012 Mar 22. PMID: 22440827 PubMed link

55. New tools for studying osteoarthritis genetics in zebrafish. Mitchell RE, Huitema LF, Skinner RH, Brunt LH, Severn C, Schulte-Merker S, Hammond CL. Osteoarthritis Cartilage.2012 Nov 15. doi:pii: S1063-4584(12)01017-5. 10.1016/j.joca.2012.11.004. [Epub ahead of print]

Casta�o Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FM, Doherty SA, Hart DJ, Hofman A, Luyten FP, Maciewicz RA, Mangino M, Metrustry S, Muir K, Peters MJ, Rivadeneira F, Wheeler M, Zhang W, Arden N, Spector TD, Uitterlinden AG, Doherty M, Lories RJ, Valdes AM, van Meurs JB. Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.Proc Natl Acad Sci U S A. 2012 May 22;109(21):8218-23. doi: 10.1073/pnas.1119899109.

Evangelou E, Valdes AM, Castano-Betancourt MC, Doherty M, Doherty S, Esko T, Ingvarsson T, Ioannidis JP, Kloppenburg M, Metspalu A, Ntzani EE, Panoutsopoulou K, Slagboom PE, Southam L, Spector TD, Styrkarsdottir U, Stefanson K, Uitterlinden AG, Wheeler M, Zeggini E, Meulenbelt I, van Meurs JB; arcOGEN consortium, the TREAT-OA consortium. The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males. Ann Rheum Dis. 2013 Jul;72(7):1264-5. doi: 10.1136/annrheumdis-2012-203182. Epub 2013 Mar 16. No abstract available.

Valdes AM, Doherty SA, Muir KR, Wheeler M, Maciewicz RA, Zhang W, Doherty M. The genetic contribution to severe post-traumatic osteoarthritis. Ann Rheum Dis. 2013 Jan 26. [Epub ahead of print]

Panoutsopoulou K, Metrustry S, Doherty S. A. e t al The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a mendelian randomisation study Ann Rheum Dis August 6 2013 doi:10.1136/annrheumdis-2013-203772

Neogi T, Soni A, Doherty SA, Laslett LL, Maciewicz RA, Hart DJ, Zhang W, Muir KR, Wheeler M, Cooper C, Spector TD, Cicuttini F, Jones G, Nevitt M, Liu Y, Arden NK, Doherty M, Valdes AM. Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis. Ann Rheum Dis. 2013 Jul 13.

Hudson G, Panoutsopoulou K, Wilson I, Southam L, Rayner NW, Arden N, Birrell F, Carluke I, Carr A, Chapman K, Deloukas P, Doherty M, McCaskie A, Ollier WE, Ralston SH, Reed MR, Spector TD, Valdes AM, Wallis GA, Wilkinson JM, Zeggini E, Samuels DC, Loughlin J, Chinnery PF; arcOGEN Consortium. No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Ann Rheum Dis. 2013 Jan;72(1):136-9. doi: 10.1136/annrheumdis-2012-201932. Epub 2012 Sep 14.

Elliott KS, Chapman K, Day-Williams A, Panoutsopoulou K, Southam L, Lindgren CM, Arden N, Aslam N, Birrell F, Carluke I, Carr A, Deloukas P, Doherty M, Loughlin J, McCaskie A, Ollier WE, Rai A, Ralston S, Reed MR, Spector TD, Valdes AM, Wallis GA, Wilkinson M, Zeggini E; GIANT consortium; arcOGEN consortium. Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Ann Rheum Dis. 2013 Jun;72(6):935-41. doi: 10.1136/annrheumdis-2012-202081. Epub 2012 Sep 6.

Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, Lopes MC, Boraska V, Esko T, Evangelou E, Hoffman A, Houwing-Duistermaat JJ, Ingvarsson T, Jonsdottir I, Jonnson H, Kerkhof HJ, Kloppenburg M, Bos SD, Mangino M, Metrustry S, Slagboom PE, Thorleifsson G, Raine EV, Ratnayake M, Ricketts M, Beazley C, Blackburn H, Bumpstead S, Elliott KS, Hunt SE, Potter SC, Shin SY, Yadav VK, Zhai G, Sherburn K, Dixon K, Arden E, Aslam N, Battley PK, Carluke I, Doherty S, Gordon A, Joseph J, Keen R, Koller NC, Mitchell S, O’Neill F, Paling E, Reed MR, Rivadeneira F, Swift D, Walker K, Watkins B, Wheeler M, Birrell F, Ioannidis JP, Meulenbelt I, Metspalu A, Rai A, Salter D, Stefansson K, Stykarsdottir U, Uitterlinden AG, van Meurs JB, Chapman K, Deloukas P, Ollier WE, Wallis GA, Arden N, Carr A, Doherty M, McCaskie A, Willkinson JM, Ralston SH, Valdes AM, Spector TD, Loughlin J. arcOGEN Consortium; arcOGEN Collaborators Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet. 2012 Sep 1;380(9844):815-23. doi: 10.1016/S0140-6736(12)60681-3.

Valdes AM, Doherty S, Muir KR, Zhang W, Maciewicz RA, Wheeler M, Arden N, Cooper C, Doherty M.Genetic contribution to radiographic severity in osteoarthritis of the knee. Ann Rheum Dis. 2012 Sep;71(9):1537-40. doi: 10.1136/annrheumdis-2012-201382. Epub 2012 May 21.

Malfait AM, Seymour AB, Gao F, Tortorella MD, Le Graverand-Gastineau MP, Wood LS, Doherty M, Doherty S, Zhang W, Arden NK, Vaughn FL, Leaverton PE, Spector TD, Hart DJ, Maciewicz RA, Muir KR, Das R, Sorge RE, Sotocinal SG, Schorscher-Petcu A, Valdes AM, Mogil JS. A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype. Ann Rheum Dis. 2012 Jun;71(6):1042-8.

Kerkhof HJ, Evangelou E, Meulenbelt I, van Meurs JB, Zeggini E, Valdes AM. Reply to “Human genetic studies on osteoarthritis from clinicians’ viewpoints”. Osteoarthritis Cartilage. 2012 Mar;20(3):250-1; author reply 252. doi: 10.1016/j.joca.2011.09.008.

Chapman K, Valdes AM. Genetic factors in OA pathogenesis. Bone. 2012 Aug;51(2):258-64. doi: 10.1016/j.bone.2011.11.026.

T Neogi et al Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis Ann Rheum Dis

Esapa CT A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation.J Bone Miner Res, Feb;27(2)2012:413-28

Esapa CT A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis. PLoS One 2012 doi: 10.1371/journal.pone.0043205

Piret SE A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation.PLoS One Sep 14; 7(9) 2012

Lories R To Wnt or not to Wnt: the bone and joint health dilemma, Nature Reviews 2013. Rheumatology, Art.nr. 10.1038, http://www.nature.com/nrrheum/journal/v9/n6/full/nrrheum.2013.25.html

Bay-Jensen AC Circulating citrullinated vimentin fragments reflect disease burden in ankylosing spondylitis and has prognostic capacity for radiographic progression Arthritis and Rheumatism, 65(4), art.nr. 10.1002/art.37843, Wiley-Blackwell, Hoboken, 2013, 972-980, http://onlinelibrary.wiley.com/doi/10.1002/art.37843/

Lodewyckx L,Tight regulation of wingless-type signalling in the articular cartilage � subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice Arthritis Research & Therapy, 14(1), Biomed Central Ltd, London, 2012, doi:10.1186/ar3695, http://arthritis-research.com/content/14/1/R16

Lodewyckx L, Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis Rheumatology, 51(11), Oxford Journals, Oxford, 2012, 1973-1978, http://rheumatology.oxfordjournals.org/content/51/11/1973.full.pdf+html

Luyten F Weak associations between structural changes on MRI and symptoms, function and muscle strength in relation to knee osteoarthritis, Knee Surg Sports Traumatol Arthrosc, Epub Feb 2, DOI 10.1007/s00167-013-2434-y, http://link.springer.com/article/10.1007%2Fs00167-013-2434-y

Baert IA Proprioceptive accuracy in women with early and established knee osteoarthritis and its relation to functional ability, postural control, and muscle strength, Clinical Rheumatology, Epub May 15 2013 , DOI 10.1007/s10067-013-2285-4, http://link.springer.com/article/10.1007%2Fs10067-013-2285-4

Baert IA Gait characteristics and lower limb muscle strength in women with early and established knee osteoarthritis, Clinical Biomechanics, 28, 2013, 40-47, http://www.sciencedirect.com/science/article/pii/S0268003312002343

Huitema LF, Apschner A, Logister I, Spoorendonk KM, Bussmann J, Hammond CL, Schulte-Merker S. Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21372-7. doi: 10.1073/pnas.1214231110. Epub 2012 Dec 12. Mitchell RE, Huitema LF, Skinner RE, Brunt LH, Severn C, Schulte-Merker S, Hammond CL.New tools for studying osteoarthritis genetics in zebrafish. Osteoarthritis Cartilage. 2013 Feb;21(2):269-78

Bos SD, Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles, Ann Rheum Dis, Oct 27, BMJ journal, Ann Rheum Dis, 2013, PMID:23104762

Williams FM, Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects, 72, 72, BMJ journal, Ann Rheum disease, 2013, 1141-8, PMID:22993228

Zeggini,E Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study, 380, , Elsevier, Lancet, 2012, 815-812, PMID:22763110

Bos SD, Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues Apr 4, BMJ journals, Ann Rheum Dis, 2012, PMID:22492780

Karunaratne A, Symmetrically reduced stiffness and increased extensibility in compression and tension at the mineralized fibrillar level in rachitic bone. Bone, Feb;52(2) 2013, 689-98, doi: 10.1016/j.bone.2012.10.029,

Bay-Jensen AC Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis. Menopause 2013 May 2013, 478-86 http://www.ncbi.nlm.nih.gov/pubmed/23615651

Karsdal MA Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure. Assay Drug Dev techonol May 2013 70-92

Siebuhr AS Matrix metalloproteinase-dependent turnover of cartilage, synovial membrane, and connective tissue is elevated in rats with collagen induced arthritis. J Transl Med. Sept. 2012 BioMed Central

Casta�o-Betancourt MC, Van Meurs JB, Bierma-Zeinstra S, Rivadeneira F, Hofman A, Weinans H, Uitterlinden AG, Waarsing JH. The contribution of hip geometry to the prediction of hip osteoarthritis. Osteoarthritis Cartilage. 2013 Jun 27. doi:pii: S1063-4584(13)00848-0.

Schiphof D, Kerkhof HJ, Damen J, de Klerk BM, Hofman A, Koes BW, van Meurs JB, Bierma-Zeinstra SM. Factors for pain in patients with different grades of knee osteoarthritis. Arthritis Care Res (Hoboken). 2013 May;65(5):695-702.

Casta�o-Betancourt MC, Rivadeneira F, Bierma-Zeinstra S, Kerkhof HJ, Hofman A, Uitterlinden AG, van Meurs JB. Bone parameters across different types of hip osteoarthritis and their relationship to osteoporotic fracture risk. Arthritis Rheum. 2013 Mar;65(3):693-700.

van Meurs JB, Uitterlinden AG Osteoarthritis year 2012 in review: genetics and genomics. Osteoarthritis Cartilage. 2012 Dec;20(12):1470-6. Review.

Leijten JC, Emons J, Sticht C, van Gool S, Decker E, Uitterlinden A, Rappold G, Hofman A, Rivadeneira F, Scherjon S, Wit JM, van Meurs J, van Blitterswijk CA, Karperien M. Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis. Arthritis Rheum. 2012 Oct;64(10):3302-12. doi: 10.1002/art.34535.

Clockaerts S, Van Osch GJ, Bastiaansen-Jenniskens YM, Verhaar JA, Van Glabbeek F, Van Meurs JB, Kerkhof HJ, Hofman A, Stricker BH, Bierma-Zeinstra SM. Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study. Ann Rheum Dis. 2012 May;71(5):642-7. doi: 10.1136/annrheumdis-2011-200092. IN PRESS at time of writing report: Kerkhof et al Prediction model for knee osteoarthritis incidence including, clinical, genetic and biochemical risk factors Ann Rheum Dis IN PRESS Evangelou E et al A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip IN PRESS ———- <———————————————————-

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