Work Package 1

WP 1: Genome Wide Association Studies To Identify OA Risk Genes

Participants:

Erasmus, Oxford, KCL, Synarc, Decode

Objectives:

To identify, using already funded genome-wide association analyses of several European cohorts and case control collections with OA data:

1. Genetic variation (SNPs and CNVs) that is strongly and consistently associated to risk of OA
2. The genetic contribution of candidate gene SNPs and SNPs in genes from candidate pathways, to risk of OA by focussed GWA analysis of tagging SNPS for these genes.